- SEBBM
- Scientific groups
- Members
- Consuls
- International
- Companies
- Conferences, courses and prizes
- Article of the month
- Science for Society
- Biochemistry and University
- Employment
- Press room
- SEBBM magazine
- Forum
SEBBM is a member of...
 |
 |
 |
 |
Collaborating entities
Drosophila lipophorin recpetors mediate the uptake of neutral lipids in oocytes and imaginal disc cells by an endocytosis-independent mechanism
| Reference: | PLoS Genet. 2011 Feb 10;7(2):e1001297 | |
| Authors: | Esmeralda Parra-Peralbo y Joaquim Culí | |
| Summary: | Lipids are constantly shuttled through the body to redistribute energy and metabolites between sites of absorption, storage and catabolism in a complex homeostatic equilibrium. In Drosophila, lipids are transported through the hemolymph in the form of lipoprotein particles, known as lipophorins. The mechanisms by which cells interact with circulating lipophorins and acquire their lipidic cargo are poorly understood. We have found that lipophorin receptor 1 and 2 (lpr1 and lpr2), two partially redundant genes belonging to the Low Density Lipoprotein Receptor (LDLR) family, are essential for the efficient uptake and accumulation of neutral lipids by oocytes and cells of the imaginal discs. Females lacking the lpr2 gene lay eggs with low lipid content and have reduced fertility, revealing a central role for lpr2 in mediating Drosophila vitellogenesis. lpr1 and lpr2 are transcribed into multiple isoforms. Interestingly, only a subset of these isoforms containing a particular LDLR type A module mediate neutral lipid uptake. Expression of these isoforms induces the extracellular stabilization of lipophorins. Furthermore, our data indicates that endocytosis is not required to mediate the uptake of neutral lipids. These findings suggest a model where lipophorin receptors promote the extracellular lipolysis of lipophorins. This model is reminiscent of the lipolytic processing of triglyceride-rich lipoproteins that occurs at the mammalian capillary endothelium, suggesting an ancient role for LDLR-like proteins in this process. |
|
| Description: |
REFERENCIA DEL GRUPO E INVESTIGADOR |
|
|
An error occurred while sending the vote.
You have already voted for this article.
An error occurred while saving the information. Try again.
You vote has been saved correctly.
|
||
| Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. [+] | |
|
de Mayo Sebastián D*, Hernández-Alvarez MI*, Segalés J*, Sorianello E, Muñoz JP, Sala D, Waget A,... |
|
| Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation [+] | |
|
de Abril Josep M. Orellana-Gavaldà, Laura Herrero, Maria Ida Malandrino, Astrid Pañeda, María Sol... |
|
| A novel GRK2/HDAC6 interaction modulates cell spreading and motility [+] | |
|
de Marzo Vanesa Lafarga, Ivette Aymerich, Olga Tapia, Federico Mayor Jr, Petronila Penela |
|
| Regulation of Ribonucleotide Reductase in Response to Iron Deficiency [+] | |
|
de Febrero Nerea Sanvisens, Mari Carmen Bañó, Mingxia Huang y Sergi Puig |
|
Did you publish an interesting article recently?
|
Send it through our application form and we will contact you. |
| Age limit: 32. |
| The selected articles will participate at the Fisher Scientific Prize which will be given during SEBBM conference, that will take place at Spain in 2012 (free registration, travel and accommodation). |
SEBBM - Sociedad Española de Bioquímica y Biología Molecular
C/ Vitruvio 8, 28006, Madrid - SPAIN
Phone. +34 91 561 33 81 - Fax. +34 91 561 32 99
Contact |
Legal warning -
Foro -
developed by Cadacual
PROTECTOR MEMBERS