- SEBBM
- Scientific groups
- Members
- Consuls
- International
- Companies
- Conferences, courses and prizes
- Article of the month
- Science for Society
- Biochemistry and University
- Employment
- Press room
- SEBBM magazine
 |
 |
 |
 |
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm
| Reference: | Nature. 2009 Jan; 457:323-26 | |
| Authors: | Weavers*, H., Prieto-Sánchez*, S., Grawe, F., García-López, A., Artero, R.,F. Wilsch-Braeuninger, M., Ruiz-Gómez, M., Skaer, H. y Delholm, B. | |
| Summary: | The nephron is the basic structural and functional unit of the vertebrate kidney. It is composed of a glomerulus, the site of ultrafiltration, and a renal tubule, along which the filtrate is modified. Although widely regarded as a vertebrate adaptation1, 'nephron-like' features can be found in the excretory systems of many invertebrates, raising the possibility that components of the vertebrate excretory system were inherited from their invertebrate ancestors2. Here we show that the insect nephrocyte has remarkable anatomical, molecular and functional similarity to the glomerular podocyte, a cell in the vertebrate kidney that forms the main size-selective barrier as blood is ultrafiltered to make urine. In particular, both cell types possess a specialized filtration diaphragm, known as the slit diaphragm in podocytes or the nephrocyte diaphragm in nephrocytes. We find that fly (Drosophila melanogaster) orthologues of the major constituents of the slit diaphragm, including nephrin, NEPH1 (also known as KIRREL), CD2AP, ZO-1 (TJP1) and podocin, are expressed in the nephrocyte and form a complex of interacting proteins that closely mirrors the vertebrate slit diaphragm complex. Furthermore, we find that the nephrocyte diaphragm is completely lost in flies lacking the orthologues of nephrin or NEPH1-a phenotype resembling loss of the slit diaphragm in the absence of either nephrin (as in human congenital nephrotic syndrome of the Finnish type, NPHS1) or NEPH1. These changes markedly impair filtration function in the nephrocyte. The similarities we describe between invertebrate nephrocytes and vertebrate podocytes provide evidence suggesting that the two cell types are evolutionarily related, and establish the nephrocyte as a simple model in which to study podocyte biology and podocyte-associated diseases. |
|
| Description: |
REFERENCIA DEL GRUPO Y/O INVESTIGADOR Para ver el artículo completo, pulse aqui |
|
|
An error occurred while sending the vote.
You have already voted for this article.
An error occurred while saving the information. Try again.
You vote has been saved correctly.
|
||
| Regulation of Ribonucleotide Reductase in Response to Iron Deficiency [+] | |
|
de Febrero Nerea Sanvisens, Mari Carmen Bañó, Mingxia Huang y Sergi Puig |
|
| Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice. [+] | |
|
de Enero Ainara Cano1, Xabier Buqué, Maite Martínez-Uña, Igor Aurrekoetxea, Ariane Menor, Juan Luis... |
|
| Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter [+] | |
|
de Diciembre Rubio-Cosials A, Sidow JF, Jiménez-Menéndez N, Fernández-Millán P, Montoya J, Jacobs HT, Coll... |
|
| Intramolecular signal transmission in a tetrameric repressor of the IclR family [+] | |
|
de Noviembre Fillet S, Krell T, Morel B, Lu D, Zhang X, Ramos JL. |
|
Did you publish an interesting article recently?
|
Send it through our application form and we will contact you. |
| Age limit: 32. |
| The selected articles will participate at the Fisher Scientific Prize which will be given during SEBBM conference, that will take place at Spain in 2012 (free registration, travel and accommodation). |
SEBBM - Sociedad Española de Bioquímica y Biología Molecular
C/ Vitruvio 8, 28006, Madrid - SPAIN
Phone. +34 91 561 33 81 - Fax. +34 91 561 32 99
Contact |
Legal warning -
Foro -
developed by Cadacual
PROTECTOR MEMBERS