Referencia

Nat Chem Biol. 2009 Dec;5(12):920-8.

Autores

Amparo Ruiz1,4,7, Asier González1,2,7, Ivan Muñoz1,5, Raquel Serrano1,6, J Albert Abrie3, Erick Strauss3 and Joaquín Ariño1,2 1. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain. 2. Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain. 3. Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa. 4. Present address: Department of Genetics and Development and Department of Microbiology and Immunology, Columbia University, New York, New York, USA. 5. Present address: Medical Research Council Protein Phosphorylation Unit, Sir James Black Centre, University of Dundee, Dundee, Scotland, UK. 6. Present address: Department of Biological Sciences, Stanford University, Stanford, California, USA. 7. These authors contributed equally to this work.

Resumen

La PPCDC es un enzima esencial, clave en la síntesis del Coenzima A. Hemos demostrado que en S. cerevisiae, en contra de lo comúnmente establecido –una flavoproteína homotrimérica-, este enzima existe como un heterotrímero. Uno de los componentes es necesariamente Ykl088w, asociado a combinaciones de Hal3 y/o Vhs3. Sorprendentemente, estas dos últimas proteínas eran conocidas como subunidades reguladoras de una proteína fosfatasa, por lo que este trabajo establece su carácter de proteínas multifuncionales o moonlighting.

Descripción

Imagen artículo Abril

REFERENCIA DEL GRUPO Y/O INVESTIGADOR
El Grupo de Biología Molecular de Levaduras se estableció en la UAB a principios de 1990. Su investigación se ha centrado principalmente en el estudio de la respuesta a estrés mediante procesos de fosfo-desfosforilación, con especial énfasis en las Ser/Thr proteína fosfatasas, habiendo descubierto y caracterizado numerosas fosfatasas de diversos organismos. Su modelo de estudio preferente es la levadura Saccharomyces cerevisiae, cuyo genoma contribuyeron a secuenciar por completo.

Para ver el artículo completo, pulse aqui

Did you publish an interesting article recently?

Send it through our application form and we will contact you. Age limit: 32.

The selected articles will participate at the Fisher Scientific Prize which will be given during SEBBM conference, that will take place at Spain (free registration, travel and accommodation).

More articles of the month

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma

01-12-2017

CIC (also known as Capicua) is a transcriptional repressor negatively regulated by RAS/MAPK signaling. Whereas the functions of Cic have been well characterized in Drosophila, little is known about its...

Read more

Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability

01-11-2017

During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, constituting in this case a source of genomic instability. To understand the...

Read more

Whi7 is an unstable cell-cycle repressor of the Start transcriptional program

01-10-2017

Start is the main decision point in eukaryotic cell cycle in which cells commit to a new round of cell division. It involves the irreversible activation of a transcriptional program...

Read more

CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation

01-09-2017

In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC). GC B-cell-to-PC transition involves...

Read more

Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa

01-08-2017

The N-acetylglucosaminidase NagZ of Pseudomonas aeruginosa catalyzes the first cytoplasmic step in recycling of muropeptides, cell-wall-derived natural products. This reaction regulates gene expression for the β-lactam resistance enzyme, β-lactamase. The...

Read more

Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.

01-07-2017

CREBBP is targeted by inactivating mutations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Here, we provide evidence from transgenic mouse models that Crebbp deletion results in deficits...

Read more

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver

01-06-2017

The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of...

Read more

Programmed mitophagy is essential for the glycolytic switch during cell differentiation

01-05-2017

Retinal ganglion cells (RGCs) are the sole projecting neurons of the retina and their axons form the optic nerve. Here, we show that embryogenesis-associated mouse RGC differentiation depends on mitophagy...

Read more

Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes

01-04-2017

The Bcl-2 (B-cell lymphoma 2) protein Bax (Bcl-2 associated X, apoptosis regulator) can commit cells to apoptosis via outer mitochondrial membrane permeabilization. Bax activity is controlled in healthy cells by...

Read more

Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c

01-03-2017

Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the DNA repair process have focused on yeast and mammals, in which histone...

Read more

Protector Members