Artículo del mes

The thermogenic activity of brown adipose tissue (BAT) and browning of white adipose tissue are important components of energy expenditure. Here we show that GPR120, a receptor for polyunsaturated fatty acids, promotes brown fat activation. Using RNA-seq to analyse mouse BAT transcriptome, we find that the gene encoding GPR120 is induced by thermogenic activation.We further show that GPR120 activation induces BAT activity and promotes the browning of white fat in mice, whereas GRP120-null mice show impaired cold-induced browning.

 

 

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Otros "Artículos del mes"

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Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

01-01-2017

Neurons depend on oxidative phosphorylation for energy generation, whereas astrocytes do not, a distinctive feature that is essential for neurotransmission and neuronal survival. However, any link between these metabolic differences...

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A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection

01-12-2016

There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these pathways;...

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In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development

In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development

01-11-2016

Class IIa Histone Deacetylases (HDACs) subfamily members are tissue-specific gene repressors with crucial roles in development and differentiation processes. A prominent example is HDAC7, a class IIa HDAC that shows...

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DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes

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01-10-2016

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Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120

Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120

01-09-2016

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IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

01-08-2016

The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune cell...

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Dissecting the role of Epidermal Growth Factor Receptor catalytic activity during liver regeneration and hepatocarcinogenesis

Dissecting the role of Epidermal Growth Factor Receptor catalytic activity during liver regeneration and hepatocarcinogenesis

01-07-2016

Different data support a role for the epidermal growth factor receptor (EGFR) pathway during liver regeneration and hepatocarcinogenesis. However, important issues, such as the precise mechanisms mediating its actions and...

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Phytochrome and retrograde signalling pathways converge to antagonistically regulate a light-induced transcriptional network

Phytochrome and retrograde signalling pathways converge to antagonistically regulate a light-induced transcriptional network

01-06-2016

Plastid-to-nucleus retrograde signals emitted by dysfunctional chloroplasts impact photomorphogenic development, but the molecular link between retrograde- and photosensory-receptor signalling has remained unclear. Here, we show that the phytochrome and retrograde...

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Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming.

01-05-2016

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p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation

01-04-2016

Disrupted organ growth leads to disease development. Hypertrophy underlies postnatal heart growth and is triggered after stress, but the molecular mechanisms involved in these processes are largely unknown. Here we...

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