Article of the month

Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic mice with nonpathological mtDNA variants reveal a nonrandom tissue-specific mtDNA segregation pattern, with few tissues that do not show segregation. The driving force for this dynamic complex pattern has remained unexplained for decades, challenging our understanding of this fundamental biological problem and hindering clinical planning for inherited diseases...

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More articles of the month

Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas

01-10-2020

C3G is a guanine nucleotide exchange factor (GEF) that regulates cell adhesion and migration by activating the GTPase Rap1. The GEF activity of C3G is stimulated by the adaptor proteins...

Expression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia

31-08-2020

The reciprocal translocation t(12;21)(p13;q22)[ETV6/RUNX1] is the most frequent chromosomal rearrangement in pediatric B-cell acute lymphoblastic leukemia(B-ALL). Long non-coding RNAs (lncRNAs) play important roles in numerous diseases and they represent an...

Evaluation of different approaches used to study membrane permeabilization by actinoporins on model lipid vesicles

30-07-2020

Release of aqueous contents from model lipid vesicles has been a standard procedure to evaluate pore formation efficiency by actinoporins, such as sticholysin II (StnII), for the last few decades...

ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity

01-07-2020

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in double-stranded RNA. A-to-I editing of RNA is a widespread posttranscriptional process that has recently emerged as an important mechanism...

Sarcoplasmic reticulum Ca2+ decreases with age and correlates with the decline in muscle function in Drosophila

29-05-2020

Sarcopenia, the loss of muscle mass and strength associated with age, has been linked to impairment of the cytosolic Ca2+ peak that triggers muscle contraction, but mechanistic details remain unknown...

Structural basis for substrate specificity and catalysis of α1,6-fucosyltransferase

30-04-2020

Core-fucosylation is an essential biological modification by which a fucose is transferred from GDP-β-L-fucose to the innermost N-acetylglucosamine residue of N-linked glycans. A single human enzyme α1,6-fucosyltransferase (FUT8) is the...

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3

31-03-2020

Polypeptide GalNAc-transferase T3 (GalNAc-T3) regulates fibroblast growth factor 23 (FGF23) by O-glycosylating Thr178 in a furin proprotein processing motif RHT 178R ↓S. FGF23 regulates phosphate homeostasis and deficiency in GALNT3...

Identification of distinct maturation steps involved in human 40S ribosomal subunit biosynthesis

29-02-2020

Technical problems intrinsic to the purification of preribosome intermediates have limited our understanding of ribosome biosynthesis in humans. Addressing this issue is important given the implication of this biological process...

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

23-01-2020

B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of...

Mip6 binds directly to the Mex67 UBA domainto maintain low levels of Msn2/4 stress-dependent mRNAs

23-12-2019

RNA-binding proteins (RBPs) participate in all steps of gene expression, underscoring their potential as regulators of RNA homeostasis. We structurally and functionally characterize Mip6, a four-RNA recognition motif (RRM)-containing RBP...

A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis
Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in animals and some bacteria and have proposed membrane organization, signaling, and antioxidant roles. We discovered…
The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature
Stl is a master repressor encoded by Staphylococcus aureus pathogenicity islands (SaPIs) that maintains integration of these elements in the bacterial chromosome. After infection or induction of a resident helper…
Self-Assembling ELR-Based Nanoparticles as Smart Drug-Delivery Systems Modulating Cellular Growth via Akt
This work investigates the physicochemical properties and in vitro accuracy of a genetically engineered drug delivery system based on elastin-like block recombinamers. The DNA recombinant technics allowed us to create…
Structure–Function of MamC Loop and Its Effect on the *in Vitro* Precipitation of Biomimetic Magnetite Nanoparticles
MamC, an integral protein of the magnetosome membrane, has recently been proposed as a strong candidate to produce biomimetic (magnetosome-like) magnetite nanoparticles that could be used as an alternative to…
Sticholysin, Sphingomyelin, and Cholesterol: A Closer Look at a Tripartite Interaction
Actinoporins are a group of soluble toxic proteins that bind to membranes containing sphingomyelin (SM) and oli- gomerize to form pores. Sticholysin II (StnII) is a member of the actinoporin…
Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour
To satisfy its high energetic demand, the brain depends on the metabolic cooperation of various cell types. For example, astrocytic-derived lactate sustains memory consolidation by serving both as an oxidizable…
Glucose restriction promotes osteocyte specification by activating a PGC-1α-dependent transcriptional program
Osteocytes, the most abundant of bone cells, differentiate while they remain buried within the bone matrix. This encasement limits their access to nutrients and likely affects their differentiation, a process…
ParB dynamics and the critical role of the CTD in DNA condensation unveiled by combined force-fluorescence measurements
/Bacillus subtilis/ ParB forms multimeric networks involving non-specific DNA binding leading to DNA condensation. Previously, we found that an excess of the free C-terminal domain (CTD) of ParB impeded DNA…
Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer
Although human epidermal growth factor receptor 2 (HER2)-targeted therapies have dramatically improved the clinical outcome of HER2-positive breast cancer patients, innate and acquired resistance remains an important clinical challenge. New…
p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton
Planar cell polarity (PCP) and intercellular junctional complexes establish tissue structure and coordinated behaviors across epithelial sheets. In multiciliated ependymal cells, rotational and translational PCP coordinate cilia beating and direct…

β‐RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9R239X mice
Coenzyme Q (CoQ) deficiency has been associated with primary defects in the CoQ biosynthetic pathway or to secondary events. In some cases, the exogenous CoQ supplementation has limited efficacy. In…
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons, a process that current therapeutic approaches cannot prevent. In PD, the typical pathological hallmark is the accumulation of…
Dynamic acetylation of cytosolic phosphoenolpyruvate carboxykinase toggles enzyme activity between gluconeogenic and anaplerotic reactions
Cytosolic phosphoenolpyruvate carboxykinase (PCK1) is considered a gluconeogenic enzyme; however, its metabolic functions and regulatory mechanisms beyond gluconeogenesis are poorly understood. Here, we describe that dynamic acetylation of PCK1 interconverts…
The Helicase PIF1 Facilitates Resection overSequences Prone to Forming G4 Structures
DNA breaks are complex lesions that can be repaired either by non-homologous end joining (NHEJ) or by homologous recombination (HR). The decision between these two routes of DNA repair is…
Preventing loss of mechanosensation by the nuclear membranes of alveolar cells reduces lung injury in mice during mechanical ventilation
The nuclear membrane acts as a mechanosensor that drives cellular responses following changes in the extracellular environment. Mechanically ventilated lungs are exposed to an abnormally high mechanical load that may…
Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria
Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective insulin treatment, but how such posttranslational modification affects mitochondrial metabolism is unclear…
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating cells, but successful metastases bypass this control through mechanisms that are poorly understood. Reactive astrocytes are key components of…
A broad atlas of somatic hypermutation allows prediction of activation-induced deaminase targets
Activation-induced deaminase (AID) initiates antibody diversification in germinal center (GC) B cells through the deamination of cytosines on immunoglobulin genes. AID can also target other regions in the genome, triggering…
Deciphering the Dynamic Transcriptional and Post-transcriptional Networks of Macrophages in the Healthy Heart and after Myocardial Injury
Our group is interested in the behavior and transcriptional regulation of macrophages in the context of complex disease environments. We have generated a whole transcriptome dataset (mRNA, miRNA, and lincRNA)…
Synaptic activity‐induced glycolysis facilitates membrane lipid provision and neurite outgrowth
La formación de nuevas neuritas es un proceso clave para el correcto desarrollo del sistema nervioso. El crecimiento neurítico requiere la generación de nuevas membranas. No obstante, los cambios metabólicos…

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15-34), antimicrobial peptides from rattlesnake venom.
La crotalicidina, un péptido del veneno de una serpiente de cascabel, tiene entre otras propiedades una potente acción antimicrobiana. Un fragmento resultante de la disección racional del péptido nativo presenta…
Functional optimization of broadly neutralizing HIV-1 antibody 10E8 by promoting membrane interactions
El anticuerpo 10E8 representa uno de los anticuerpos anti-VIH con mayor cobertura de neutralización y potencia descrito a día de hoy. Su epítopo se localiza en una región próxima a…
Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL
La legionelosis o enfermedad del legionario es una neumonía potencialmente fatal, causada por la bacteria Legionella pneumophila. Durante la infección, la bacteria trasloca un gran número de proteínas, llamadas efectores…
Late rDNA Condensation Ensures Timely Cdc14 Release and Coordination of Mitotic Exit Signaling with Nucleolar Segregation
El nucléolo, además de su función esencial en la biogénesis de los ribosomas, juega también un papel importante en múltiples procesos celulares. Así, en este orgánulo se mantienen secuestradas proteínas clave para…
Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma
CIC (also known as Capicua) is a transcriptional repressor negatively regulated by RAS/MAPK signaling. Whereas the functions of Cic have been well characterized in Drosophila, little is known about its…
Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability
During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, constituting in this case a source of genomic instability. To understand the…
Whi7 is an unstable cell-cycle repressor of the Start transcriptional program
Start is the main decision point in eukaryotic cell cycle in which cells commit to a new round of cell division. It involves the irreversible activation of a transcriptional program…
CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation
In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC). GC B-cell-to-PC transition involves…
Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa
The N-acetylglucosaminidase NagZ of Pseudomonas aeruginosa catalyzes the first cytoplasmic step in recycling of muropeptides, cell-wall-derived natural products. This reaction regulates gene expression for the β-lactam resistance enzyme, β-lactamase. The…
Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.
CREBBP is targeted by inactivating mutations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). Here, we provide evidence from transgenic mouse models that Crebbp deletion results in deficits…

Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver
The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of…
Programmed mitophagy is essential for the glycolytic switch during cell differentiation
Retinal ganglion cells (RGCs) are the sole projecting neurons of the retina and their axons form the optic nerve. Here, we show that embryogenesis-associated mouse RGC differentiation depends on mitophagy…
Bax transmembrane domain interacts with prosurvival Bcl-2 proteins in biological membranes
The Bcl-2 (B-cell lymphoma 2) protein Bax (Bcl-2 associated X, apoptosis regulator) can commit cells to apoptosis via outer mitochondrial membrane permeabilization. Bax activity is controlled in healthy cells by…
Histone chaperone activity of Arabidopsis thaliana NRP1 is blocked by cytochrome c
Higher-order plants and mammals use similar mechanisms to repair and tolerate oxidative DNA damage. Most studies on the DNA repair process have focused on yeast and mammals, in which histone…
The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes
The thermogenic activity of brown adipose tissue (BAT) and browning of white adipose tissue are important components of energy expenditure. Here we show that GPR120, a receptor for polyunsaturated fatty…
Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes
Neurons depend on oxidative phosphorylation for energy generation, whereas astrocytes do not, a distinctive feature that is essential for neurotransmission and neuronal survival. However, any link between these metabolic differences…
A genome-wide screening uncovers the role of CCAR2 as an antagonist of DNA end resection
There are two major and alternative pathways to repair DNA double-strand breaks: non-homologous end-joining and homologous recombination. Here we identify and characterize novel factors involved in choosing between these pathways;…
In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development
Class IIa Histone Deacetylases (HDACs) subfamily members are tissue-specific gene repressors with crucial roles in development and differentiation processes. A prominent example is HDAC7, a class IIa HDAC that shows…
DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes
Inflammasomes are cytosolic multiprotein complexes in macrophages. They assemble after infection- or stress-associated stimuli, activating both caspase-1-mediated inflammatory cytokine secretion and pyroptosis. Increased inflammasome activity resulting from gene mutations is…
Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena…
Aims: The ferric uptake regulator (Fur) is the main transcriptional regulator of genes involved in iron homeostasis in most prokaryotes. FurA from Anabaena sp. PCC 7120 contains five cysteine residues…

IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation
The role of cytokines in establishing specific transcriptional programmes in innate immune cells has long been recognized. However, little is known about how these extracellular factors instruct innate immune cell…
Dissecting the role of Epidermal Growth Factor Receptor catalytic activity during liver regeneration and hepatocarcinogenesis
Different data support a role for the epidermal growth factor receptor (EGFR) pathway during liver regeneration and hepatocarcinogenesis. However, important issues, such as the precise mechanisms mediating its actions and…
Phytochrome and retrograde signalling pathways converge to antagonistically regulate a light-induced transcriptional network
Plastid-to-nucleus retrograde signals emitted by dysfunctional chloroplasts impact photomorphogenic development, but the molecular link between retrograde- and photosensory-receptor signalling has remained unclear. Here, we show that the phytochrome and retrograde…
Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming.
During the process of reprogramming to induced pluripotent stem (iPS) cells, somatic cells switch from oxidative to glycolytic metabolism, a transition associated with profound mitochondrial reorganization. Neither the importance of…
p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
Disrupted organ growth leads to disease development. Hypertrophy underlies postnatal heart growth and is triggered after stress, but the molecular mechanisms involved in these processes are largely unknown. Here we…
Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling
AIRAPL (arsenite-inducible RNA-associated protein-like) is an evolutionarily conserved regulator of cellular proteostasis linked to longevity in nematodes, but its biological function in mammals is unknown. We show herein that AIRAPL-deficient…
Infection exposure is a causal factor in B-precursor acute lymphoblastic leukemia as a result of Pax5 inherited susceptibility
Earlier in the past century, infections were regarded as the most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However, there is a lack of relevant biologic evidence…
Structural and functional insights into Escherichia coli α2-macroglobulin endopeptidase snap-trap inhibition
The survival of commensal bacteria requires them to evade host peptidases. Gram-negative bacteria from the human gut microbiome encode a relative of the human endopeptidase inhibitor, α2-macroglobulin (α2M). Escherichia coli…
NF-κB activation impairs somatic cell reprogramming in ageing
Ageing constitutes a critical impediment to somatic cell reprogramming. We have explored the regulatory mechanisms that constitute age-associated barriers, through derivation of induced pluripotent stem cells (iPSCs) from individuals with…
miR-58 family and TGF-β pathways regulate each other in Caenorhabditis elegans
Despite the fact that microRNAs (miRNAs) modulate the expression of around 60% of protein-coding genes, it is often hard to elucidate their precise role and target genes. Studying miRNA families…

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest
Blocking mitotic progression has been proposed as an attractive therapeutic strategy to impair proliferation of tumour cells. However, how cells survive during prolonged mitotic arrest is not well understood. We…
Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition
Common variable immunodeficiency (CVID), the most frequent primary immunodeficiency characterized by loss of B-cell function, depends partly on genetic defects, and epigenetic changes are thought to contribute to its aetiology…
Role for RNA:DNA hibrids in origin-independent replication priming in a eukaryotic system
DNA replication initiates at defined replication origins along eukaryotic chromosomes, ensuring complete genome duplication within a single S-phase. A key feature of replication origins is their ability to control the…
Un gel durmiente, clave en la formación de la metástasis
Metastasis is responsible for most cancer-related deaths, and, among common tumor types, melanoma is one with great potential to metastasize. Here we study the contribution of epigenetic changes to the…
Head-to-head antisense transcription and R-loop formation promotes transcriptional activation
The mechanisms used by antisense transcripts to regulate their corresponding sense mRNAs are not fully understood. Herein, we have addressed this issue for the vimentin (VIM) gene, a member of…
p73 is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF and TGFβ signaling
Vasculogenesis, the establishment of the vascular plexus and angiogenesis, branching of new vessels from the preexisting vasculature, involves coordinated endothelial differentiation, proliferation and migration. Disturbances in these coordinated processes may…
NF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation
Monocyte-to-osteoclast conversion is a unique terminal differentiation process that is exacerbated in rheumatoid arthritis and bone metastasis. The mechanisms implicated in upregulating osteoclast-specific genes involve transcription factors, epigenetic regulators and…
Photoperiodic control of carbon distribution during the floral transition in Arabidopsis
Ortiz-Marchena MI1, Albi T, Lucas-Reina E, Said FE, Romero- Campero FJ, Cano B, Ruiz MT, Romero JM, Valverde F.
COPII Coat Composition Is Actively Regulated by Luminal Cargo Maturation
Javier Manzano-Lopez, Ana M. Perez-Linero, Auxiliadora Aguilera-Romero, Maria E. Martin, Tatsuki Okano, Daniel Varon Silva, Peter H. Seeberger, Howard Riezman, Kouichi Funato, Veit Goder, Ralf E. Wellinger, Manuel Muñiz
Apicobasal polarity controls lymphocyte adhesion to hepatic epithelial cells
Natalia Reglero-Real, Adrián Álvarez-Varela, Eva Cernuda-Morollón, Jorge Feito, Beatriz Marcos-Ramiro, Laura Fernández-Martín, Maria José Gómez-Lechón, Jordi Muntané, Pilar Sandoval, Pedro L. Majano, Isabel Correas, Miguel A. Alonso, Jaime Millán

Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability
Marta Muñoz-Barrera and Fernando Monje-Casas
XTACC3–XMAP215 association reveals an asymmetric interaction promoting microtubule elongation
Gulnahar B. Mortuza ,TommasoCavazza, Maria Flor Garcia-Mayoral, Dario Hermida, Isabel Peset, Juan G. Pedrero, Nekane Merino, Francisco J. Blanco, JeppeLyngsø, Marta Bruix, Jan Skov Pedersen, Isabelle Vernos& Guillermo Montoya
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death
Martorell-Riera A, Segarra-Mondejar M, Muñoz JP, Ginet V, Olloquequi J, Pérez-Clausell J, Palacín M, Reina M, Puyal J, Zorzano A, Soriano FX.
Phosphorylation at Ser-181 of oncogenic KRAS is required for tumor growth
Barceló C, Paco N, Morell M, Alvarez-Moya B, Bota-Rabassedas N, Jaumot M, Vilardell F, Capella G, Agell N.
Regulation of Plant Stem Cell Quiescence by a Brassinosteroid Signaling Module
Josep Vilarrasa-Blasi, Mary-Paz González-García, David Frigola, Norma Fàbregas, Konstantinos G. Alexiou, Nuria López-Bigas, Susana Rivas, Alain Jauneau, Jan U. Lohmann, Philip N. Benfey, Marta Ibañes and Ana I. Caño-Delgado.
Regulation of pri-mi RNA Processing by a Long Noncoding RNA Transcribed from an Ultraconserved Region
Liz J, Portela A, Soler M, Gómez A, Ling H, Michlewski G, Calin GA, Guil S, Esteller M.
The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts
Emilia Herrera-Moyano, Xénia Mergui, María L. García-Rubio, Sonia Barroso y Andrés Aguilera.
Control of Cdc28 CDK1 by a stress-induced lncRNA
Mariona Nadal-Ribelles (1,3), Carme Solé (1,3), Zhenyu Xu (2), Lars M. Steinmetz (2), Eulàlia de Nadal (1,4) and Francesc Posas (1,4) (1) Cell Signaling Unit, Departament de Ciències Experimentals i…
ATM specifically mediates repair of double-strand breaks with blocked DNA ends
Alejandro Álvarez-Quilón, Almudena Serrano-Benítez, Jenna Ariel Lieberman, Cristina Quintero, Daniel Sánchez-Gutiérrez, Luis M. Escudero, Felipe Cortés-Ledesma
An o2-sensitive glomus cell-stem cell synapse induces carotid body growth in chronic hipoxia
Aida Platero-Luengo,1 Susana González-Granero,2,3 Rocío Duran,1 Blanca Díaz-Castro,1 José I. Piruat,1 José Manuel García-Verdugo,2,3 Ricardo Pardal,1,* and José López-Barneo1,3,* 1 Departamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de…

R Loops Are Linked to Histone H3 S10 Phosphorylation and Chromatin Condensation
Maikel Castellano-Pozo, José María Santos-Pereira, Ana García-Rondón, Sonia Barroso, Eloísa Andújar, Mónica Pérez-Alegre, Tatiana García-Muse y Andrés Aguilera.
Inhibition of the Mitotic Exit Network in response to damaged telomeres
Mauricio Valerio-Santiago, Ana Isabel de los Santos-Velázquez, Fernando Monje-Casas
Arabidopsis J-Protein J20 Delivers the First Enzyme of the Plastidial Isoprenoid Pathway to Protein Quality Control.
Pablo Pulido, Gabriela Toledo-Ortiz, Michael A. Phillips, Louwrance P. Wright, y Manuel Rodríguez-Concepción.
PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation
Lorenzo de la Rica, Javier Rodríguez-Ubreva, Mireia García, Abul Islam, José Miguel Urquiza, Henar Hernando, Jesper Christensen, Kristian Helin, Carmen Gómez-Vaquero y Esteban Ballestar
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion
Jorge de la Rosa, José M.P. Freije, Rubén Cabanillas, Fernando G. Osorio, Mario F. Fraga, M. Soledad Fernández-García, Roland Rad, Víctor Fanjul, Alejandro P. Ugalde, Qi Liang, Haydn M. Prosser…
Rad51 replication fork recruitment is required for DNA damage tolerance.
Román González-Prieto, Ana M Muñoz-Cabello, María J Cabello-Lobato and Félix Prado
In vivo JNK activation in pancreatic β-cells leads to glucose intolerance caused by insulin resistance in pancreas
Lanuza-Masdeu Jordi, Arévalo María Isabel, Vila Cristina, Barberà Albert, Gomis Ramon, Caelles Carme.
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation
Isabel Romero Camarero, Xiaoyu Jiang, Yasodha Natkunam, Xiaoqing Lu, Carolina Vicente Dueñas, Ines González Herrero, Teresa Flores, Juan Luis García, George McNamara, Christian Kunder, Shuchun Zhao, Víctor Segura, Lorena Fontán…
Exploring new biological functions of amyloids: bacteria cell agglutination mediated by host protein aggregation.
Marc Torrent, David Pulido, Maria VictòriaNogués, Ester Boix.
Prochlorococcus can use the Pro1404 transporter to take up glucose at nanomolar concentrations in the Atlantic Ocean
Muñoz-Marin MC, Luque I, Zubkov MV, Hill PG, Diez J & García-Fernandez JM

Cytoneme-Mediated Delivery of Hedgehog Regulates the Expression of Bone Morphogenetic Proteins to Maintain Germline Stem Cells in Drosophila
Patricia Rojas Ríos, Isabel Guerrero Vega y Acaimo González Reyes.
PRESYNAPTIC SELF-DEPRESSION AT DEVELOPING NEOCORTICAL SYNAPSES
Antonio Rodríguez-Moreno, Ana González-Rueda, Abhishek Banerjee, A. Louise Upton, Michael T. Craig MT and Ole Paulsen
Glucose-Induced β-Catenin Acetylation Enhances Wnt Signaling in Cancer
Ana Chocarro-Calvo, Jose Manuel García-Martínez, Soraya Ardila-González, Antonio De la Vieja and Custodia García-Jiménez
Nek9 phosphorylation of NEDD1/GCP-WD contributes to Plk1 control of gamma-tubulin recruitment to the mitotic centrosome
Sdelci S*, Schütz M*, Pinyol R, Bertran MT, Regué L, Caelles C, Vernos I, Roig J. (*These authors contributed equally to this work)
CDK2-dependent activation of PARP-1 is required for hormonal gene regulation in breast cancer cells
Roni H. G. Wright, Giancarlo Castellano, Jaume Bonet, Francois Le Dily, Jofre Font-Mateu, Cecilia Ballaré, A. Silvina Nacht, Daniel Soronellas1, Baldo Oliva and Miguel Beato(CRG, Barcelona)
Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice.
Vicente-Duenas, C., L. Fontan, I. Gonzalez-Herrero, I. Romero-Camarero, V. Segura, M.A. Aznar, E. Alonso-Escudero, E. Campos-Sanchez, L. Ruiz-Roca, M. Barajas-Diego, A. Sagardoy, J.I. Martinez-Ferrandis, F. Abollo-Jimenez, C. Bertolo, I. Penuelas…
Un RNA viroidal redirige a la DNA ligasa 1 del huésped a actuar como RNA ligasa
María-Ángeles Nohales, Ricardo Flores y José-Antonio Daròs
β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer
Stephan P Tenbaum, Paloma Ordóñez-Morán, Isabel Puig, Irene Chicote, Oriol Arqués, Stefania Landolfi, Yolanda Fernández, José Raúl Herance, Juan D Gispert, Leire Mendizabal, Susana Aguilar, Santiago Ramón y Cajal, Simó…
A role for tRNA modifications in genome structure and codon usage
Eva Maria Novoa, Mariana Pavon-Eternod, Tao Pan, Lluis Ribas de Pouplana
γ-Glutamylcysteine detoxifes reactive oxygen species by acting as glutathione peroxidase-1 cofactor
Quintana-Cabrera, R.; Fernández-Fernández, S.; Bobo-Jiménez, V.; Escobar, J.; Sastre, J; Almeida, A.; Bolaños, J.P.

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis.
Sebastián D*, Hernández-Alvarez MI*, Segalés J*, Sorianello E, Muñoz JP, Sala D, Waget A, Liesa M, Paz JC, Gopalacharyulu P, Oresic M, Pich S, Burcelin R, Palacín M, Zorzano A…
Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation
Josep M. Orellana-Gavaldà, Laura Herrero, Maria Ida Malandrino, Astrid Pañeda, María Sol Rodríguez-Peña, Harald Petry, Guillermina Asins, Sander Van Deventer, Fausto G. Hegardt, Dolors Serra.
A novel GRK2/HDAC6 interaction modulates cell spreading and motility
Vanesa Lafarga, Ivette Aymerich, Olga Tapia, Federico Mayor Jr, Petronila Penela
Regulation of Ribonucleotide Reductase in Response to Iron Deficiency
Nerea Sanvisens, Mari Carmen Bañó, Mingxia Huang y Sergi Puig
Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice
Ainara Cano, Xabier Buqué, Maite Martínez-Uña, Igor Aurrekoetxea, Ariane Menor, Juan Luis García-Rodríguez2, Shelly Lu, José María Mato, Begoña Ochoa y Patricia Aspichueta
Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter
Rubio-Cosials A, Sidow JF, Jiménez-Menéndez N, Fernández-Millán P, Montoya J, Jacobs HT, Coll M, Bernadó P, Solà M.
Intramolecular signal transmission in a tetrameric repressor of the IclR family
Fillet S, Krell T, Morel B, Lu D, Zhang X, Ramos JL.
Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease
Valles-Ortega J*, Duran J*, Garcia-Rocha M, Bosch C, Saez I, Pujadas L, Serafin A, Cañas X, Soriano E, Delgado-García JM, Gruart A, Guinovart JJ. * Coautores
Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress
Carme Solé1,3, Mariona Nadal-Ribelles1,3, Claudine Kraft2, Matthias Peter2, Francesc Posas1 and Eulàlia de Nadal1 1. Departament de Ciències Experimentals i de la Salut, Cell Signalling Unit, Universitat Pompeu Fabra (UPF)…
Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice
Natalia Rodríguez-Muela, Francisco Germain, Guillermo Mariño, Patrick S Fitze and Patricia Boya.

Drosophila lipophorin recpetors mediate the uptake of neutral lipids in oocytes and imaginal disc cells by an endocytosis-independent mechanism
Esmeralda Parra-Peralbo y Joaquim Culí
Light-dependent gene regulation by a coenzyme B12-based photoreceptor
Juan Manuel Ortiz-Guerrero, María Carmen Polanco, Francisco J. Murillo, S. Padmanabhan, y Montserrat Elías-Arnanz
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing
Melo S, Villanueva A, Moutinho C, Davalos V, Spizzo R, Ivan C, Rossi S, Setien F, Casanovas O, Simo-Riudalbas L, Carmona J, Carrere J, Vidal A, Aytes A, Puertas S…
Structure of a Preternary Complex Involving a Prokaryotic NHEJ DNA Polymerase
Nigel C. Brissett*, Maria Jose Martin*, Robert S. Pitcher, Julie Bianchi, Raquel Juarez, Andrew J. Green, Gavin C. Fox, Luis Blanco', and Aidan J. Doherty'. (* coauthors) ('co-corresponding authors)
Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin
Muñoz IG, Yébenes H, Zhou M, Mesa P, Serna M, Park AY, Bragado-Nilsson E, Beloso A, de Cárcer G, Malumbres M, Robinson CV, Valpuesta JM, Montoya G.
Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase
Manchado E, Guillamot M, de Cárcer G, Eguren M, Trickey M, García-Higuera I, Moreno S, Yamano H, Cañamero M, Malumbres M.
Distributed Biological Computation with Multicellular Engineered Networks
Sergi Regot*, Javier Macia*, Núria Conde, Kentaro Furukawa, Jimmy Kjellén, Tom Peeters, Stefan Hohmann, Eulàlia de Nadal, Francesc Posas* y Ricard Solé*
A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells
Melo SA, Moutinho C, Ropero S, Calin GA, Rossi S, Spizzo R, Fernandez AF, Davalos V, Villanueva A, Montoya G, Yamamoto H, Schwartz Jr, Esteller M.
Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes
Marta Navarrete and Alfonso Araque
Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain
Marta Nadal, Philippe Mas, Alexandre G. Blanco, Carme Arnan, Maria Solà, Darren J. Hart y Miquel Coll

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex
F. Javier Pérez-Victoria(1)*, Guillermo Abascal-Palacios(2)*, Igor Tascón(2), Andrey Kajava(3), Javier G. Magadán(1), Erik P. Pioro(4), Juan S. Bonifacino(1), Aitor Hierro(2) *Equal contribution. (1) Cell Biology and Metabolism Program, Eunice Kennedy Shriver National…
Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat
Nereida Jiménez-Menéndez1,2, Pablo Fernández-Millán1, Anna Rubio-Cosials1, Carme Arnan1,2, Julio Montoya3, Howard T Jacobs4, Pau Bernadó2, Miquel Coll1,2, Isabel Usón1,5 & Maria Solà1
Retinoid X receptor α controls innate inflammatory responses through the up-regulation of chemokine expression
Vanessa Núñeza,1, Daniel Alamedaa,1, Daniel Ricoa,2, Rubén Motab, Pilar Gonzalob, Marta Cedenillaa, Thierry Fischerc, Lisardo Boscád, Christopher K. Glasse, Alicia G. Arroyob, and Mercedes Ricotea,3 Departments of aRegenerative Cardiology and bVascular…
Cysteine string protein-α prevents activity-dependent degeneration in GABAergic synapses
Pablo García-Junco-Clemente , Gloria Cantero ,Leonardo Gómez-Sánchez , Pedro Linares-Clemente, Jose A. Martínez-López , Rafael Luján, Rafael Fernández-Chacón.
A Postincision-Deficient TFIIH Causes Replication Fork Breakage and Uncovers Alternative Rad51- or Pol32-Mediated Restart Mechanisms
María Moriel-Carretero* y Andrés Aguilera* *Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain
Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis
Amparo Ruiz1,4,7, Asier González1,2,7, Ivan Muñoz1,5, Raquel Serrano1,6, J Albert Abrie3, Erick Strauss3 and Joaquín Ariño1,2 1. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain. 2. Institut de Biotecnologia i…
The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm
Weavers*, H., Prieto-Sánchez*, S., Grawe, F., García-López, A.,Artero,R.,F. Wilsch-Braeuninger, M., Ruiz-Gómez, M., Skaer, H. y Delholm, B.
The asymmetric / symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways
Xavier Rovira (1), Jean-Philippe Pin (2) and Jesús Giraldo (1) 1- Laboratory of Systems Pharmacology and Bioinformatics, Institut de Neurociencies and Unitat de Bioestadıstica, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain. 2-…
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1
Herrero-Méndez, A.; Almeida, A.; Fernández, E.; Maestre, C.; Moncada, S.; y Bolaños, J.P.
The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP.
Querol-Audí J, Casañas A, Usón I, Luque D, Castón JR, Fita I, Verdaguer N.

Overactivation of the MEK/ERK Pathway in Liver Tumor Cells Confers Resistance to TGF-B–Induced Cell
Laia Caja, Patricia Sancho, Esther Bertran, Daniel Iglesias-Serret, Joan Gil, Isabel Fabregat
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Sonia A. Melo(1), Santiago Ropero(1), Catia Moutinho(1), Lauri A Aaltonen(2), Hiroyuki Yamamoto(3), George A Calin(4), Simona Rossi(4), Agustin F Fernandez(1), Fatima Carneiro(5), Carla Oliveira(5), Bibiana Ferreira(1), Chang-Gong Liu(4), Alberto Villanueva(6)…
A molecular framework for light and gibberellin control of cell elongation.
Miguel de Lucas1,4, Jean-Michel Davière1,4, Mariana Rodríguez-Falcón1,4, Mariela Pontin1, Juan Manuel Iglesias-Pedraz1, Séverine Lorrain2, Christian Fankhauser2, Miguel Angel Blázquez3, Elena Titarenko1 & Salomé Prat1 Departamento de Genética Molecular de Plantas…