Referencia

Ref: Cell. 2014 Jan 16;156(1-2):291-303. doi: 10.1016/j.cell.2013.12.013.

Autores

Aida Platero-Luengo,1 Susana González-Granero,2,3 Rocío Duran,1 Blanca Díaz-Castro,1 José I. Piruat,1 José Manuel García-Verdugo,2,3 Ricardo Pardal,1,* and José López-Barneo1,3,* 1 Departamento de Fisiología Médica y Biofísica, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain 2 Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Universidad de Valencia, 46071 Valencia, Spain 3 Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain

Resumen

Neural stem cells (NSCs) exist in germinal centers of the adult brain and in the carotid body (CB), an oxy- gen-sensing organ that grows under chronic hyp- oxemia. How stem cell lineage differentiation into mature glomus cells is coupled with changes in phys- iological demand is poorly understood. Here, we show that hypoxia does not affect CB NSC prolif- eration directly. Rather, mature glomus cells expres- sing endothelin-1, the O2-sensing elements in the CB that secrete neurotransmitters in response to hypoxia, establish abundant synaptic-like contacts with stem cells, which express endothelin receptors, and instruct their growth. Inhibition of glomus cell transmitter release or their selective destruction markedly diminishes CB cell growth during hypoxia, showing that CB NSCs are under the direct ‘‘synap- tic’’ control of the mature O2-sensitive cells. Thus, glomus cells not only acutely activate the respira- tory center but also induce NSC-dependent CB hypertrophy necessary for acclimatization to chronic hypoxemia.

Descripción

El mecanismo por el cual los estímulos ambientales y la demanda fisiológica son capaces de modular los nichos neurógenicos en los organismos adultos es una cuestión importante en el campo de las células madre. Este artículo revela cómo un estímulo hipóxico es capaz de activar la proliferación del nicho neurogénico del cuerpo carotídeo a través del establecimiento de una estructura tipo sinapsis entre la célula glómica neuronal madura y la célula progenitora de donde proviene.

grupo

REFERENCIA DEL GRUPO INVESTIGADOR

Laboratorio de Fisiopatología de células madre neurales. Instituto de Biomedicina de Sevilla-IBiS. Nuestro grupo estudia la biología de células progenitoras en el sistema nervioso adulto y su comunicación con los demás componentes del nicho donde residen. Estas célulasparticipan en el desarrollo, mantenimiento y reparación de los tejidos neurales y una disrupción en el funcionamiento de estos nichos puede conllevar la aparición de patologías, como procesos cancerígenos o degeneración.

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