Referencia

Neuron. 2013 Jan 9;77(1):35-42. doi: 10.1016/j.neuron.2012.10.035

Autores

Antonio Rodríguez-Moreno, Ana González-Rueda, Abhishek Banerjee, A. Louise Upton, Michael T. Craig MT and Ole Paulsen

Resumen

A central tenet of most theories of synaptic modification during cortical development is that correlated activity drives plasticity in synaptically-connected neurons. Unexpectedly, however, using sensory-evoked activity patterns recorded from the developing mouse cortex in vivo, the synaptic learning rule that we uncover here relies solely on the presynaptic neuron. A burst of three presynaptic spikes followed, within a restricted time window, by a single presynaptic spike induces robust long-term depression (LTD) at developing layer 4-to-layer 2/3 synapses. This presynaptic spike pattern-dependent LTD (p-LTD) can be induced by individual presynaptic layer 4 cells, requires presynaptic NMDA receptors and calcineurin, and is expressed presynaptically. However, in contrast to spike timing-dependent LTD, p-LTD is independent of postsynaptic and astroglial signalling. This spike pattern-dependent learning rule complements timing-based rules and is likely to play a role in the pruning of synaptic input during cortical development.

Descripción

Este trabajo describe el descubrimiento de una nueva forma de plasticidad en el sistema nervioso (una nueva forma de depresión de larga duración, LTD). Esta nueva forma de LTD (p-LTD) se induce por un patrón de estimulación natural (existente en el cerebro in vivo) consistente en 3 espigas a alta frecuencia (50-200 Hz) seguida de una espiga individual unos milisegundos (50-200) más tarde. Esta p-LTD existe a nivel de neuronas individuales y requiere de la activación de receptores de glutamato de tipo NMDA y de la activación de la fosfatasa calcineurina a nivel presináptico. En contra de las formas hebbianas de plasticidad esta forma de LTD no requiere de la fisiología de la célula postsináptica ni tampoco de las células gliales.

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REFERENCIA DEL GRUPO INVESTIGADOR

Antonio Rodríguez-Moreno es Director del Laboratorio de Neurociencia Celular y Plasticidad de la Universidad Pablo de Olavide. Su grupo de investigación se dedica al estudio de los fenómenos plásticos del cerebro y de los sistemas de señalización implicados. Ana González-Rueda (Laboratory of Physiology, University of Cambridge) colabora en la búsqueda de nuevas reglas de plasticidad en el cerebro de los mamíferos.

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