Nat Chem Biol. 2009 Dec;5(12):920-8.


Amparo Ruiz1,4,7, Asier González1,2,7, Ivan Muñoz1,5, Raquel Serrano1,6, J Albert Abrie3, Erick Strauss3 and Joaquín Ariño1,2 1. Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain. 2. Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain. 3. Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa. 4. Present address: Department of Genetics and Development and Department of Microbiology and Immunology, Columbia University, New York, New York, USA. 5. Present address: Medical Research Council Protein Phosphorylation Unit, Sir James Black Centre, University of Dundee, Dundee, Scotland, UK. 6. Present address: Department of Biological Sciences, Stanford University, Stanford, California, USA. 7. These authors contributed equally to this work.


La PPCDC es un enzima esencial, clave en la síntesis del Coenzima A. Hemos demostrado que en S. cerevisiae, en contra de lo comúnmente establecido –una flavoproteína homotrimérica-, este enzima existe como un heterotrímero. Uno de los componentes es necesariamente Ykl088w, asociado a combinaciones de Hal3 y/o Vhs3. Sorprendentemente, estas dos últimas proteínas eran conocidas como subunidades reguladoras de una proteína fosfatasa, por lo que este trabajo establece su carácter de proteínas multifuncionales o moonlighting.


Imagen artículo Abril

El Grupo de Biología Molecular de Levaduras se estableció en la UAB a principios de 1990. Su investigación se ha centrado principalmente en el estudio de la respuesta a estrés mediante procesos de fosfo-desfosforilación, con especial énfasis en las Ser/Thr proteína fosfatasas, habiendo descubierto y caracterizado numerosas fosfatasas de diversos organismos. Su modelo de estudio preferente es la levadura Saccharomyces cerevisiae, cuyo genoma contribuyeron a secuenciar por completo.

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