Nature. 2009 Jan; 457:323-26


Weavers*, H., Prieto-Sánchez*, S., Grawe, F., García-López, A.,Artero,R.,F. Wilsch-Braeuninger, M., Ruiz-Gómez, M., Skaer, H. y Delholm, B.


Hemos establecido que los nefrocitos de Drosophila (células encargadas del filtrado de la hemolinfa) poseen diafragmas de filtración análogos a nivel molecular, estructural y funcional a los presentes en los podocitos renales, que permiten el paso selectivo de moléculas a la orina durante el ultrafiltrado de la sangre en vertebrados. Este hecho permite establecer a los nefrocitos de Drosophila como un sistema muy útil para estudiar la fisiología renal en los seres humanos, tanto en condiciones normales como patológicas (revisado en Simons, M. and Huber, T. B. (2009). Flying podocytes. Kidney Int 75, 455-7.)


Imagen artículo Marzo

El grupo de la Dra. Mar Ruiz Gómez, Investigadora Científica del CSIC, en el Centro de Biología Molecular Severo Ochoa (CBMSO), trabaja en el la caracterización funcional de las proteínas IRM, de la superfamilia de las inmunoglobulinas en distintos contextos celulares: mesodermo y nefrocitos de Drosophila melanogaster. El equipo esta formado por el investigador principal, tres investigadores postdoctorales y un estudiante predoctoral. El artículo presentado, realizado en colaboración con el grupo de la Dra. Helen Skaer en Cambridge, ha formado parte del tema de trabajo desarrollado por la Dra. Silvia Prieto Sánchez para la obtención del grado de Doctor.

Para ver el artículo completo, pulse aqui

Did you publish an interesting article recently?

Send it through our application form and we will contact you. Age limit: 32.

The selected articles will participate at the Award to the best article of young people of the SEBBM which will be given during SEBBM conference, that will take place at Spain (free registration, travel and accommodation).

More articles of the month

A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis


Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond. These lipids are found in animals and some bacteria and have proposed membrane organization, signaling, and antioxidant roles. We discovered...

Read more

The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature


Stl is a master repressor encoded by Staphylococcus aureus pathogenicity islands (SaPIs) that maintains integration of these elements in the bacterial chromosome. After infection or induction of a resident helper...

Read more

Self-Assembling ELR-Based Nanoparticles as Smart Drug-Delivery Systems Modulating Cellular Growth via Akt


This work investigates the physicochemical properties and in vitro accuracy of a genetically engineered drug delivery system based on elastin-like block recombinamers. The DNA recombinant technics allowed us to create...

Read more

Structure–Function of MamC Loop and Its Effect on the *in Vitro* Precipitation of Biomimetic Magnetite Nanoparticles


MamC, an integral protein of the magnetosome membrane, has recently been proposed as a strong candidate to produce biomimetic (magnetosome-like) magnetite nanoparticles that could be used as an alternative to...

Read more

Sticholysin, Sphingomyelin, and Cholesterol: A Closer Look at a Tripartite Interaction


Actinoporins are a group of soluble toxic proteins that bind to membranes containing sphingomyelin (SM) and oli- gomerize to form pores. Sticholysin II (StnII) is a member of the actinoporin...

Read more

Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour


To satisfy its high energetic demand, the brain depends on the metabolic cooperation of various cell types. For example, astrocytic-derived lactate sustains memory consolidation by serving both as an oxidizable...

Read more

Glucose restriction promotes osteocyte specification by activating a PGC-1α-dependent transcriptional program


Osteocytes, the most abundant of bone cells, differentiate while they remain buried within the bone matrix. This encasement limits their access to nutrients and likely affects their differentiation, a process...

Read more

ParB dynamics and the critical role of the CTD in DNA condensation unveiled by combined force-fluorescence measurements


/Bacillus subtilis/ ParB forms multimeric networks involving non-specific DNA binding leading to DNA condensation. Previously, we found that an excess of the free C-terminal domain (CTD) of ParB impeded DNA...

Read more

Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer


Although human epidermal growth factor receptor 2 (HER2)-targeted therapies have dramatically improved the clinical outcome of HER2-positive breast cancer patients, innate and acquired resistance remains an important clinical challenge. New...

Read more

p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton


Planar cell polarity (PCP) and intercellular junctional complexes establish tissue structure and coordinated behaviors across epithelial sheets. In multiciliated ependymal cells, rotational and translational PCP coordinate cilia beating and direct...

Read more

Protector Members