Trends Pharmacol Sci. 2010 Jan;31(1):15-21


Xavier Rovira (1), Jean-Philippe Pin (2) and Jesús Giraldo (1) 1- Laboratory of Systems Pharmacology and Bioinformatics, Institut de Neurociencies and Unitat de Bioestadıstica, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain. 2- CNRS,UMR 5203, Institut de Genomique fonctionnelle, Montpellier, France and INSERM, U661, Montpellier, France and Universite Montpellier 1 and 2, Montpellier, France.


Estudios recientes sugieren que un mismo tipo de receptor acoplado a proteína G puede activar diversas vías de señalización, siendo algunas de estas vías independientes de la activación de proteínas G. Además, ciertos ligandos han demostrado tener la capacidad de activar preferentemente una de estas vías. Esta característica, denominada selectividad funcional, puede ser clave para determinar el modo de acción de los fármacos. En el presente trabajo, se analiza este fenómeno en el contexto de la homodimerización de receptores utilizando como herramienta la modelización matemática.


Imagen artículo Febrero

Xavier Rovira se encuentra en su último año de tesis dentro del grupo de investigación del Dr. Jesús Giraldo. El Laboratorio de Farmacología de Sistemas y Bioinformática (Instituto de Neurociencias, Universidad Autónoma de Barcelona) es un equipo interdisciplinario compuesto por químicos, biólogos, informáticos y matemáticos. El grupo ha desarrollado nuevas metodologías combinando modelización matemática y molecular para el estudio de la interacción ligando-receptor y la transducción de señales

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