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Fecha:
27.05.2020  STATUS
Lugar:
Virtual - on line
Website:
https://www.workcast.com/registe...

In this new webinar from The CRISPR Journal and GEN, Dr. Wen Xue, University of Massachusetts Medical School, will present a modular delivery strategy for homology-directed repair by combining lipid nanoparticle delivery of Cas9 mRNA with adeno-associated viruses (AAV) encoding a sgRNA and a repair template. In a mouse model of human hereditary tyrosinemia, gene correction efficiency of >6% in hepatocytes was achieved after a single application, suggesting the potential of Cas9-based therapeutic genome editing.

Dr. Xue will also discuss advances in base editing, a highly promising tool to correct single-base pathogenic mutations, including new results on a chemically modified mRNA-encoded adenine base editor (ABE) that mediates robust base editing.
A live Q&A session will follow the presentation, offering you a chance to pose questions to Dr. Xue.

More information and registration

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